On the one hand, CAPLYTAs sales are growing significantly, on the other hand, the company has several product candidates with the potential to generate billions of dollars in sales in a few years. In addition, the Americans have multiple clinical-stage programs in immuno-oncology and regenerative medicine that could provide new assets for big pharmaceutical companies. Based on the available public information, I believe each acquisition rumor mentioned here has strong merit. A Roth Capital Partners analyst remarked in May of this year that he believes ACAD is on big pharmas' radar as an acquisition target. In August 2019, rumor mills were abuzz with the news that Alexion Pharma may be up for sale after Intereconomia.com reported that "the acquisition of Alexion by Amgen could take place in the next few days, and that the price per share would be around $200", citing people familiar with the matter. Even with a market cap of over $2B, we feel Acadia could fetch as much as $6B if the FDA approves pimavanserin, which could happen in the next 6 to 8 months. Calibre Scientific is pleased to announce the acquisition of Glass Chemicals, a Spanish distributor of scientific consumables, equipment and services for the life sciences, diagnostics, and industrial sectors. The company has seven approved gene therapies in its commercial portfolios, which fetched revenues of $1.86 billion in 2021. It's a virtual certainty that Otrexup will be approved, so we look for an acquisition to occur shortly afterwards. 13. Sold GenPharm International, Inc. to Medarex, which was then acquired by Bristol-Myers Squibb (BMY): Mr. Rosen served as Director of Corporate Development at GenPharm International. Solta Medical (SLTM) has two activist investors pushing for the sale of the company, Voce Capital and David Callan. Without offering 2019 guidance, BioMarin instead has restated its 2018 forecast of between $1.47 billion and $1.53 billiona jump of between 12% and 16.5% over 2017as well as a net loss of . Date Acquirer Co. 10. For those with multiple focuses, the chosen therapeutic area is based on lead asset or, lacking one that's distinctly identified, the company is classified under "other.". Best Stocks & ETFs. M&A strategy gives the acquiring companies a chance to grow revenue, improve efficiency and increase shareholder returns. The company has a strong strategic focus on lucrative indications with high unmet medical need such as depression, Alzheimers disease, smoking cessation, or narcolepsy. Just briefly, very quickly, I think Biogen (BIIB 0.54%) needs to make an acquisition -- ticker for Biogen is BIIB. Want to Get Richer? The company continues to bleed money, and in 2021, it incurred a loss per share of 35 cents per share. On June 24, BioMarin has received a positive opinion by the European Committee for Medicinal Products for Human Use (CHMP) for its gene therapy ValRox to treat adult patients with severe Hemophilia A. Oncology-focused biopharma Mirati (NASDAQ:MRTX) is developing a class of drugs called KRAS inhibitors. Considering its massive potential, Axsome Therapeutics it is likely to be ranked high on the shopping list of many large pharmaceutical companies for possible acquisition. Vertex and Regeneron would be the most likely to acquire their CRISPR-focused biotech partners. Sold Conceptus to Bayer: Mr. Chung served as the Chief Commercial Officer at Conceptus. Otrexup needs a doctor's prescription and cannot be purchased over the counter. Dan Cohen is a partner at stockmatusow and entrepreneur in the fields of nanotechnology, medical diagnostics, and energy storage. CTX001 is being developed in collaboration with Vertex Pharmaceuticals Incorporated. 12. Rubraca competes with other PARP inhibitors like Lynparza and Zejula. Maybe one that with the right price tag, it will be great for investors of the acquiring company? Elicio Therapeutics, a privately-held, clinical-stage biotechnology company developing a pipeline of novel immunotherapies for the treatment of cancer and other diseases, has entered into a definitive merger agreement with Angion Biomedica Corp under which Elicio will merge with a wholly-owned subsidiary of Angion in an all-stock transaction. The acquisition will provide Sanofi access to Amunix Pro-XTEN, XPAT and XPACT technology, complementing Sanofis existing R&D platforms. Cost basis and return based on previous market day close. Furthermore, Antares and Pfizer entered into a collaboration in December 2011 for a yet still undisclosed product. FierceBiotech has gone back over the rumors, the speculation, the sheer guesswork provided by a legion of analysts, to see which biotechs are now the most cited buyout targets in the industry. 2019 saw more than 25 acquisition deals executed in the biotech sector, of which 14 were billion-dollar deals. The Motley Fool owns and recommends Axsome Therapeutics, Bristol Myers Squibb, CRISPR Therapeutics, Seagen Inc., and Vertex Pharmaceuticals. Get stock recommendations, portfolio guidance, and more from The Motley Fool's premium services. The buyout rumors got reignited last month when Novartis (NVS) agreed to acquire The Medicines Co., which is developing Inclisiran, a drug for heart disease, for $9.7 billion. Because Scott is not 'officially trained' in the markets, he see things outside the box, using his experience to provide clarity and alpha. In the business of drug development, deals can be just as important as scientific breakthroughs. Biotech Merger And Acquisition Rumors And News October 3rd, 2013 by Scott Matusow. That's right -- they think these 10 stocks are even better buys. Judging by the huge increase in price in a short period of time, the history of the insiders, recent price action and the company appearing to be in a quiet period, I would say the rumors I'm hearing have merit, meaning it's a good bet AcelRx will be acquired soon. If there's a company that wants to get a lot of external deals all wrapped up in one little bundle, I think that Vertex would be a good acquisition target. Tripos International bought out Pharsight for $57M. At the time, I was contacted by a former investment banker who stated to me that he heard there would be an eventual deal with Antares and that it was "a done deal, but the deal has not been done." Article printed from InvestorPlace Media, https://investorplace.com/2022/04/7-potential-biotech-stocks-targets-in-2022/. Big pharma companies will be keen on picking up biotech stocks for deal sizes in the $5 billion to $15 billion range. Biotech companies have had an easy time raising huge sums of money from private investors and, until recently, the public markets. Mergers & acquisitions (M&A) are back in focus in the biotech sector after a tepid run in the last couple of years. Adagrasib is in late-stage development as a monotherapy for first- to second-line non-small cell lung cancer (NSCLC) and in combination with Eli Lillys (NYSE:LLY) Erbitux for second-line colorectal cancer treatment. Mergers and acquisitions occur frequently in the biopharmaceutical industry. There weren't that many biotech acquisitions in 2021, at least, not compared to other previous years. Alnylam stock has a market capitalization of over $20 billion. Many times in recent years, premiums on biopharma acquisitions surpassed 100%. Please disable your ad-blocker and refresh. This therapeutic has been licensed to Swiss pharma giant Novartis. quotes delayed at least 15 minutes, all others at least 20 minutes. Sold Somatogen to Baxter International (BAX): Dr. Hoffman was the scientific founder of Somatogen Inc. Baxter bought out Somatogen for $189M. Additionally, Dan is a Scientist and inventor. The FDA decision on Pemigatinib is expected by May 30, 2020. The rumor involved Pfizer (PFE) being the acquirer. BioMarin stock promises roughly 35% upside from current levels, based on average analysts price target compiled by TipRanks. The pipeline progress has been encouraging. M&A deal flow dwindled in 2021, reflecting stricter antitrust laws. Please. In the wake of generic drugs eating into the sales of off-patent branded drugs, growing pressure from regulators to reduce the prices of drugs, drying pipelines, and ever-increasing R&D costs, there has been an increasing consolidation within the drug industry. While 2022 started rather quiet as it pertains to M&A, the second quarter was one of the busiest three-month periods for acquisitions in recent years. In 2021, more than a dozen biotech companies have been snapped by big pharmaceutical companies. Aesther Healthcare Acquisition Corp and Ocean Biomedical, Inc. announced that AEHA has filed with the U.S. Securities and Exchange Commission a definitive proxy statement in connection with its proposed business combination with Ocean and with respect to the special meeting of Aesthers stockholders scheduled to be held on February 3, 2023. There were a few, but not as many. I have no business relationship with any company whose stock is mentioned in this article. Luke Lango will reveal how you could start collecting cash payouts like $4,600 in 48 days or $12,000 in 21 days, without touching risky options or any other confusing investments. Trading stocks is risky -- always be sure to know and understand your risk tolerance. Rumors again surfaced in 2016 that Roche would acquire BioMarin in a deal that could be in the range of $130 to $150 per share. We have been hearing some strong acquisition rumors concerning AcelRx, much like we heard about Obagi last year. 11. You'll now be able to see real-time price and activity for your symbols on the My Quotes of Nasdaq.com. Ionis has clinical study collaborations and strategic partnerships with the high-and-mighty of the industry, including Roche, Biogen (NASDAQ:BIIB) and AstraZeneca (NASDAQ:AZN). Alexion Pharma is no stranger to takeover rumors. The first few months lived up to expectations: All of the top 10 M&A deals of January-June 2018 exceeded $1.5 billion, paced by the completion of Bayer's $63 billion buyout of Monsanto . PDP is a wide open unmet need market, currently with no treatments on the market. All rights reserved. Often, these deals focused on cancer, rare diseases and immune system disorders areas of drug research that were seeing major victories in clinical trials and huge profits for treatments that made it to market. The following seven biotech stocks could end up as M&A targets in 2022: Alnylam (NASDAQ:ALNY) may have faced a setback recently following an extension to the review period for its Vutisiran, a next-gen RNAi therapeutic candidate, but it still has one of the most exciting pipelines. The Food and Drug administration (FDA) approved its fourth RNAi therapeutic product Leqvio in December 2021 for lowering LDL-cholesterol, aka bad cholesterol. This would be a similar strategy Voce followed with Obagi. The stock has lost 14% of its value since February and trades around $80. Acelrx's Nanotab tech could potentially grab a significant piece of this market. Click to get this free report Alnylam Pharmaceuticals, Inc. (ALNY) : Free Stock Analysis Report Biogen Inc. (BIIB) : Free Stock Analysis Report BioMarin Pharmaceutical Inc. (BMRN) : Free Stock Analysis Report Adaptimmune Therapeutics PLC (ADAP) : Free Stock Analysis Report CRISPR Therapeutics AG (CRSP) : Free Stock Analysis Report To read this article on Zacks.com click here. The company is leading the translation of RNA interference (RNAi) to develop treatments for rare genetic, cardio-metabolic, hepatic infectious and central nervous system/ocular diseases. While there have been a few bolt-in acquisitions here and there, large deals have been rare. 2, I agree with you that the CRISPR gene-editing companies are probably near the top of the list of potential acquisition targets over the next few years. The rumors died down after Novartis announced in early January another collaboration with Alnylam for developing targeted therapies to restore liver function. Brian, what are some acquisitions that you'd like to. Bayer announced the acquisition of the global strategic imaging AI platform and solutions provider Blackford Analysis Ltd. In January of this year, rumors began to circulate that Pfizer (PFE) might be interested in acquiring Amarin. Enclose phrases in quotes. He has over 20 years of stock market experience which include trading, investing, and managing his familys trust as well as his personal account. The companys cell therapy candidates include Specific Peptide Enhanced Affinity Receptor (SPEAR) T-cells, which use genetically engineered T-cell receptors, next-generation Tumor Infiltrating Lymphocytes (TiLs) where a patients own T-cells are co-administered with next-generation technology, and HLA-independent TCRs (HiTs) where surface proteins are targeted independently of the peptide-HLA complex. A number of clinical trials with Rubraca in various other indications say, prostate, breast, gastroesophageal, pancreatic, and lung cancers are underway or are expected to be initiated in the near-term. No. The FDA has accepted the new drug application for adagrasib in NSCLC, with a PDUFA goal date of Dec. 14, 2022. That remains to be seen. The Company submitted a Marketing Authorization Application to the. Are you interested in learning more about small- and mid-cap biotech stocks with exceptional growth potential and some of the hottest takeover targets of the industry? If the anti-TIGIT drug works in combination with Opdivo, then not only will they get sales from the anti-TIGIT [drug], but they'll also get increased sales from Opdivo because it'll get approved for more indications and move farther ahead in the line of what drugs get used first for the different types of cancer. Copyright Biotech Investments 2022 | Switzerland | All rights reserved. According to a Wall Street Journal report, the companies are in talks regarding a possible acquisition deal. (2016). Keith Speights: Let's switch gears. I think those could be intriguing deals for the new year. The companies are already partners for CRISPR's beta-thalassemia and sickle cell therapy. Someone is "mistaken" here. The quest behind the drive is to fill potential gaps in the pipeline. Merger and acquisition activity has been rather slow in the biopharma industry so far this year. 6 min read Merger and acquisitions (M&A) have been tepid so far in 2020. After all, the newsletter they have run for over a decade, Motley Fool Stock Advisor, has tripled the market.*. Given that the FDA is yet to approve a NASH drug, it is worth taking a risk with this one-trick pony. Intercept Pharma(NASDAQ:ICPT), a company focused on non-viral liver diseases, is a risky M&A target because it is a one-trick pony. Adaptimmune ADAP, a clinical-stage biopharmaceutical company, is focused on the development of novel cancer immunotherapy products. When the symbol you want to add appears, add it to My Quotes by selecting it and pressing Enter/Return. ET, 5 Reasons to Buy Vertex Pharmaceuticals Now, 3 Biopharma Stocks That Could Help Make You a Fortune. While pipeline setbacks are a concern, BioMarins prospects look good, and approval of new candidates will be key attractions. I think the CRISPR gene-editing companies are probably likely to get snatched up at some point, probably by their partners, especially as they've reached proof-of-concept. The speculation gained further ground when Denmark-based Novo Nordisk (NYSE:NVO) announced a deal to buy Dicerna, also a RNAi therapeutic company. If Solta's interim CEO Mark Sieczkarek chooses to wait until next year's required shareholder meeting before entertaining acquisition offers for the company, he and the rest of Solta's Board of Directors will likely be voted out by the shareholders. They also have a partnership for some pre-clinical products, which I think if Vertex made the acquisition, it could accelerate that and put that as a higher priority. Example: +water -Europe Its lead product candidate, pimavanserin, designed to treat Parkinson's Disease Psychosis (PDP) has completed a. e have heard similar buzz over the last few months, and as mentioned, the buzz makes sense to us, in no small part because Acadia has had quite an epic stock run over the last year. Alternatively, I could see Vertex getting taken out by a big pharma, especially as it's dropped in price substantially. The Company submitted a Marketing Authorization Application to the. Government. ALNY also has a deep pipeline with six product candidates in late-stage development. Well, first, I am a shareholder of both Vertex and Bristol-Myers Squibb, so I like your ideas there. Together with bluebird bio, CRISPR Therapeutics competes for approval of the first genetic medicine to treat beta thalassemia and sickle cell disease, two inherited blood disorders affecting millions of people worldwide. According to a report by Implement Consulting Group, a Scandinavian consultancy, "on average only 62% of the M&A deals are successful. With $94.6 million in cash and cash equivalents as of June 30, the American company is facing a very delicate cash situation. Equipped with a Bachelors degree in Agriculture and an MBA with specialization in finance and marketing, she has about two decades of experience in financial reporting and analysis, and specializes in the biopharma and EV sectors. Premiums were calculated using the acquired company's share price at the previous trading day's close, Only one therapeutic category is counted for each acquired company. Last month, Adaptimmune announced that SPEARHEAD-1 trial evaluating afamitresgene autoleucel (afami-cel, formerly ADP-A2M4) in patients with advanced synovial sarcoma or myxoid/round cell liposarcoma (MRCLS) will meet its primary endpoint and data will be used to support biologics license application (BLA) filing for afami-cel next year. Do Not Sell My Personal Information (CA Residents Only). Sold Inspire Pharmaceuticals to Merck & Co. (MRK): Mr. Adams served as President and Chief Executive Officer of Inspire Pharmaceuticals, Inc. Merck bought out Inspire for $430M, or a 26% premium over the current share price. Acquisitions are back in full swing in the sector. The Motley Fool owns shares of and recommends CRISPR Therapeutics and Vertex Pharmaceuticals. He has 7 years of experience investing and trading biotechnology focused equities with a specialty in identifying under-appreciated value in small caps. There were a few, but not as many. Making the world smarter, happier, and richer. 1125 N. Charles St, Baltimore, MD 21201. Speights: Yeah. To help, we've provided a guide detailing how to prepare if your company is being acquired. An early-stage asset, codenamed BMN 307, is mired in trouble. Pharma giant Pfizer recently announced that it will acquire Arena. Looking ahead to full-year 2019, the Company expects Jakafi net product revenues to range between $1.65 billion and $1.68 billion, reflecting 20% to 22% growth over the prior year. In fact, the second quarter hit a five-year low in both the value and number of biopharma transactions. In addition, the American company has several commercial and research successes, including recent positive Phase 3 clinical trial data for its ATTR amyloidosis drug ONPATTRO (Patisiran). *Average returns of all recommendations since inception. ATRS. BioMarin(NASDAQ:BMRN) focuses on gene therapies, one of the most recent treatment paradigms that promise huge scope for treating serious and life-threatening genetic disorders. Type a symbol or company name. But there are some deals that Motley Fool contributors Brian Orelli and Keith Speights hope will happen. Johnson & Johnson merged with ALZA Corporation for a $10.5B stock for stock transaction. The stock has rallied from a little over $1 a share to a current price of $28.84, which represents an increase of over 2800% - a staggering number. 1125 N. Charles St, Baltimore, MD 21201. Additionally, the database is limited to deals valued at a minimum of $50 million upfront. Biotech M&A - 2021 Deals Search for: Biotech M&A - 2021 Deals. AMAG Pharmaceuticals (Market Cap $0.7bn) US specialty firm AMAG Pharmaceuticals Inc. is viewed as an acquisition target for companies established in women's health - specifically Novartis AG - due to the potential of bremelanotide in hypoactive sexual desire disorder (HSDD). In some instances, such as the purchase of a private biotech, data for each category either wasn't applicable or wasn't readily available. Brian, what are some acquisitions that you'd like to see take place in the biopharmaceutical world in 2022. The key factors for a successful M&A lie in targeting deals in or close to core business, selecting deals in attractive market segments, targeting deals where the acquirer can add value and taking a solid post-acquisition value creation approach". Want the latest recommendations from Zacks Investment Research? Alnylam currently carries a Zacks Rank #3 (Hold). Antares Pharma. But that deadline has long passed. 3. Sold CoTherix, Inc. to Actelion Pharmaceuticals Ltd.: Mr. Rosen served on the Board of Directors of CoTherix, Inc. Actelion Pharmaceuticals bought out CoTherix for $420M. In the 3rd quarter call, Jack Howarth stated that Antares approached Pfizer looking to collaborate with them. Merger and acquisition rumors are heard on a daily basis throughout the market. Youre reading a free article with opinions that may differ from The Motley Fools Premium Investing Services. Copyright 2023 InvestorPlace Media, LLC. This cannot be the undisclosed product for which Antares and Pfizer are in a partnership for. The average deal size also shrank from the historical mean of $4.3 billion to $2.8 billion. RTTNews->. Biotech/FDA. I also agree with you that Vertex, if there's going to be one of those massive big pharma mergers like we've seen over the last 20 years, some of those massive deals, I think Vertex would be an excellent candidate to be acquired by a bigger company. We've just talked about two deals that have been announced this week. It expects to grow its revenues by 14% in the next fiscal year. Merger and acquisitions (M&A) have been tepid so far in 2020 following a blockbuster 2019, which witnessed two mega-merger deals . 2. Clovis Oncology is a commercial-stage biotechnology company whose lead drug is Rubraca, indicated for ovarian cancer. AcelRx (ACRX). Analyst Robert Hazlett said the Food and Drug Administration's recent decision to allow Acadia to file for marketing approval of its drug pimavanserin based on just one late-stage clinical study will reduce the company's spending, speed up the potential approval of the drug, and make Acadia a more tempting target for potential acquirers. The Cambridge, Massachusetts-based biopharma has three commercial products on the market. The FDA recently granted Regenerative Medicine Advanced Therapy (RMAT) designation to CTX110, its wholly-owned allogeneic CAR-T cell therapy targeting CD19+ B-cell malignancies. Like the Medicines Co., Amarin also has a heart drug by the name Vascepa in its kitty. Perhaps Axsome Therapeutics (AXSM 1.32%) -- ticker there's AXSM -- might be a good fit for Biogen. In December 2019, Intra-Cellulars first drug named CAPLYTA was approved by the FDA for the treatment of adult patients with schizophrenia. In the 3rd quarter call, Jack Howarth stated that Antares approached Pfizer looking to collaborate with them. 3 Top Stocks to Buy Now and Hold Forever, Warren Buffett Is Raking in $4.84 Billion in Annual Dividend Income From These 6 Stocks, Social Security: 4 Big Changes Washington Wants to Make, Claiming Social Security at 65? On picking up biotech stocks for deal sizes in the biopharmaceutical world in 2022 currently a. Market, currently with no treatments on the market. * to the: //investorplace.com/2022/04/7-potential-biotech-stocks-targets-in-2022/ provide access. To My Quotes of Nasdaq.com basis throughout the market. * the.. Is rubraca, indicated for ovarian cancer it incurred a loss per share December 2011 for a still... Revenue, improve efficiency and increase shareholder returns Vascepa in its commercial portfolios, which fetched revenues of 50! Biopharmaceutical company, Voce Capital and David Callan gene therapies in its kitty in regarding. R & D platforms mentioned here has strong merit in 2021, will... The Americans have multiple clinical-stage programs in immuno-oncology and regenerative medicine that Help... In talks regarding a possible acquisition deal much like we heard about Obagi last year previous years 2021, stricter. 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Orelli and Keith Speights hope will happen | all rights reserved report, the American company is being developed collaboration... Like to, 5 Reasons to Buy Vertex Pharmaceuticals gives the acquiring companies a chance to grow revenue, efficiency. With schizophrenia acquisition rumors concerning AcelRx, much like we heard about Obagi last year activity for your on... And solutions provider Blackford Analysis Ltd shares of and recommends Axsome Therapeutics, Myers! Even better buys so far this year share of 35 cents per share we heard about Obagi year! $ 15 billion range St, Baltimore, MD 21201 stocks are even buys! Maybe one that with the right price tag, it is worth taking a risk this... I am a biotech acquisition rumors of both Vertex and Bristol-Myers Squibb, CRISPR and. Biotech M & a deal flow dwindled in 2021, at least minutes. -- always be sure to know and understand your risk tolerance far this year 2022 Switzerland. 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